The present study has been undertaken to investigate the effect of different extract of leaves of Jatropha curcas Linn. on antisecretory activity in pylorus ligated rats. Treatment with petroleum ether (60-800C), chloroform, methanol and aqueous extract of J. curcas (200 and 400 mg /kg, p.o.) and ranitidine (50 mg/kg, p.o.) were administered 1 h prior to pyloric ligation and experimental parameters were observed. In pylorus ligated rats, gastric content was analyzed for PH, total acidity and ulcer index. The dose dependant significant reduction in gastric volume, pH, total acidity, and ulcer index were observed after treatment with 200 mg/kg and 400 mg/kg of different J. curcas extracts as compared to the normal control group. The present study provides a strong evidence of antisecretory activity of different extracts of J. curcas against pylorus ligated rats.
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